periodontal disease

EuroPerio10: The best EuroPerio yet

EuroPerio10, the world’s leading congress in periodontology and implant dentistry organised in Copenhagen on 15-18 June by the European Federation of Periodontology (EFP), was the most exciting EuroPerio yet.

Professor Phoebus Madianos, chair of EuroPerio10, said: “EuroPerio attracts the best speakers, scientists, and clinicians from around the world to the Olympic Games of dental congresses. This is the main event organised by the EFP and the growing success of EuroPerio is mainly due to the scientific programme which delivers the present and future in the science and practice of periodontology and implant dentistry.”

Key stats:

·         More than 7,000 participants from 110 countries.

·         66% of participants under 45 years of age and 33% under 35 years.

·         Original research presented in over 900 scientific abstracts.

·         41 scientific sessions on emerging issues of interest for practitioners, scientists and academics.

·         Over 130 top speakers from more than 30 countries.

·         50% less printed materials than EuroPerio9.

Research was presented on novel topics such as the role of artificial intelligence in the diagnosis and treatment of periodontitis. New evidence was revealed on previously investigated areas including the links between gum disease and heart conditions, diabetes, premature birth and lung function, and the long-term outcome of periodontal treatment. Plus: the first European guideline on how to treat advanced (stage IV) periodontitis.

Professor Andreas Stavropoulos, EFP president, said: “The EFP is the global benchmark in gum health and gum diseases. The main mission of the EFP is to raise awareness about the importance of gum disease and gum health, and our motto is periodontal health for a better life. This is what we communicate to society and to politicians so that we can influence decision making and improve oral health. Our main educational activity is EuroPerio, and this edition has attracted a very young audience, which clearly indicated the interest in periodontology of the young generation of colleagues. While this edition has now closed its doors, we look forward to seeing the dental community at EuroPerio11 from 14 to 17 May 2025 in Vienna, Austria.”

EFP, global benchmark in periodontology

The European Federation of Periodontology (EFP, ww.efp.org) is a non-profit organisation dedicated to promoting awareness of periodontal science and the importance of gum health. Its guiding vision is “periodontal health for a better life.”

Founded in 1991, the EFP is a federation of 37 national periodontal member societies that represents more than 16,000 periodontists, dentists, researchers, and oral-health professionals from Europe and around the world. It supports evidence-based science in periodontal and oral health, and it promotes events and campaigns aimed at both professionals and the public.

The EFP organises EuroPerio, the world’s leading congress in periodontology and implant dentistry, as well as other important professional and expert events such as Perio Master Clinic and Perio Workshop. The annual Gum Health Day on May 12, organised by the EFP and its member societies, brings key messages on gum health to millions of people across the world.

The EFP also organises workshops and outreach campaigns with its partners: projects to date have covered the relationship between periodontal disease and diabetes, cardiovascular disease, and caries, as well as women’s oral health during pregnancy.

The EFP’s Journal of Clinical Periodontology is the most authoritative scientific publication in this field. The federation also publishes JCP Digest, a monthly digest of research, and the Perio Insight magazine, which features experts’ views and debates.

The EFP’s work in education is also highly significant, notably its accreditation programme for postgraduate education in periodontology and implant dentistry.

The EFP has no professional or commercial agenda.

Gum disease linked to Covid-19 complications

Covid-19 patients are at least three times more likely to experience complications if they also have gum disease, according to research published in the Journal of Clinical Periodontology1, the official publication of the European Federation of Periodontology (EFP).

The study of more than 500 patients with Covid-19 found that those with gum disease were 3.5 times more likely to be admitted to intensive care, 4.5 times more likely to need a ventilator, and almost nine times more likely to die compared to those without gum disease.

Blood markers indicating inflammation in the body were significantly higher in Covid-19 patients who had gum disease compared to those who did not, suggesting that inflammation may explain the raised complication rates.

“The results of the study suggest that the inflammation in the oral cavity may open the door to the Coronavirus becoming more violent,” said Professor Lior Shapira, EFP president-elect. “Oral care should be part of the health recommendations to reduce the risk for severe Covid-19 outcomes.”

Periodontitis, a serious form of gum disease, affects up to half of all adults worldwide2. Periodontitis causes inflammation of the gums and, if left untreated, inflammation can spread throughout the body. Covid-19 is associated with an inflammatory response that may be fatal. This study investigated the relationship between periodontitis and Covid-19 complications.

This was a nationwide case-control study conducted in Qatar, which has electronic health records containing medical and dental data. The study included 568 patients diagnosed with Covid-19 between February and July 2020. Of these, 40 had complications (intensive care unit [ICU] admission, ventilator requirement, or death) and 528 did not. Information was collected on gum disease and other factors that might be associated with Covid-19 complications including body mass index (BMI), smoking, asthma, heart disease, diabetes, and high blood pressure. Data was also obtained on blood levels of chemicals related to inflammation in the body.

Of 568 Covid-19 patients in the study, 258 (45%) had gum disease. After adjusting for age, sex, BMI, smoking status, and other conditions, the odds ratios for Covid-19 complications in patients with gum disease, compared to those without gum disease, were 3.67 (95% confidence interval [CI] 1.46–9.27) for all Covid-19 complications, 3.54 (95% CI 1.39–9.05) for ICU admission, 4.57 (95% CI 1.19–17.4) for ventilator requirement, and 8.81 (95% CI 1.00–77.7) for death.

The authors stated: “If a causal link is established between periodontitis and increased rates of adverse outcomes in Covid-19 patients, then establishing and maintaining periodontal health may become an important part of the care of these patients.”

Professor Mariano Sanz of the Complutense University of Madrid, Spain, one of the study’s authors, noted that oral bacteria in patients with periodontitis can be inhaled and infect the lungs, particularly in those using a ventilator. He said: “This may contribute to the deterioration of patients with Covid-19 and raise the risk of death. Hospital staff should identify Covid-19 patients with periodontitis and use oral antiseptics to reduce transmission of bacteria.”

Professor Shapira said that the association between periodontitis and lung diseases including asthma, pneumonia, and chronic obstructive pulmonary disease (COPD) is well established3. He said: “This study adds further evidence to the links between oral health and respiratory conditions. Periodontitis is a common disease but can be prevented and treated.”

Professor Nicola West, EFP secretary general, added: “This study highlights another association between gum disease and our systemic health and reiterates the need for ongoing, lifelong dental care for people susceptible to gum disease and a strong preventive approach to periodontitis for populations as a whole.”

What you can do to prevent gum disease:

  • Brush your teeth carefully more than once a day using a manual or powered toothbrush.
  • Clean between your teeth daily using an interdental brush (or floss if the gaps are too tight).
  • Specific mouth rinses or toothpastes can be used on top of cleaning to reduce inflammation.
  • Do not smoke, maintain a healthy weight, eat a balanced diet, exercise, reduce stress.
  • If you have diabetes, control your blood sugar.

Those seeking more information are advised to visit The British Society of Periodontology and Implant Dentistry’s website: www.bsperio.org.uk.

References
1) Marouf N, Cai W, Said KN, et al. Association between periodontitis and severity of COVID-19 infection: a case-control study. J Clin Periodontol. 2021. doi:10.1111/jcpe.13435. The article was first published as an accepted article on 1 February 2021. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the version of record.
2) Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci. 2017;11:72–80.
3) Gomes-Filho IS, da Cruz SS, Trindade SC, et al. Periodontitis and respiratory diseases: A systematic review with meta-analysis. Oral Dis. 2020;26:439–446.

Gum inflammation – when and how to intervene to prevent disease

This article explores the periodontal disease process, as well as how to use the BPE to best effect and what sort of preventive regimen may support patients with their at-home efforts.

Brought to you by Johnson & Johnson Ltd., the makers of LISTERINE®.

Gingivitis and periodontitis are a continuum of the same inflammatory disease. However, it does not follow that gingivitis will always progress to periodontitis.1

Rather, it is considered that: ‘The weight of the evidence indicates that the prevention of gingival inflammation prevents periodontitis’.1

Plaque control is at the heart of tackling the periodontal disease challenge, as stated by Chapple and colleagues (2015), ‘[…] the most important risk factor for periodontitis is the accumulation of a plaque biofilm at and below the gingival margin, within which dysbiosis develops and is associated with an inappropriate and destructive host inflammatory immune response. Plaque removal and/or control is therefore fundamentally important in the prevention of periodontal diseases.’2

Classifying gingival health

At the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions, working group 1 classified gingival heath and gingival conditions, as well as creating a summary table of diagnostic features for defining oral health and gingivitis in a number of clinical situations.3

The group concluded that there are four levels of periodontal health:4

1. Pristine periodontal health, with a structurally sound and uninflamed periodontium

2. Well-maintained clinical periodontal health, with a structurally and clinically sound (intact) periodontium

3. Periodontal disease stability, with a reduced periodontium

4. Periodontal disease remission/control, with a reduced periodontium

They also wrote: ‘The reliability and reproducibility of any case definition for health, gingival or periodontal conditions relies upon standardization of probing protocols, which is only possible with the implementation of an ISO probe. The current International Organization for Standardization (ISO) for periodontal probes is – ISO 21672, but requires updating in order to define the features of a global standard periodontal probe. These characteristics are:

1. Tip diameter 0.5 mm

2. Cylindrical tine structure

3. Constant force limiter of 0.25 N

4. 15mm scale with precise individual or banded millimetre markings

5. A taper of 1.75°.’3

Using the BPE

A probe-led system, the BPE, was first introduced to the UK’s dental profession in 1986, and has been revised over the years – most recently in 2011 and then 2016.5,6

Guidance suggests that a WHO periodontal probe, which has a ball-shaped tip 0.5mm in diameter and a narrow shaft marked with black a line between 3.5mm and 5.5mm from the tip, is used to record a patient’s BPE. Some probes also have a black band between 8.5mm and 11.5mm.7

To record the BPE for adults:5

1. The teeth are divided into six sextants – upper right, upper anterior, upper left, lower right, lower anterior and lower left

2. All teeth in each sextant are examined, except for 3rd molars (unless the 1st and / or 2nd molar(s) is / are missing). For a sextant to qualify for examination, at least two natural teeth must be present.

3. The probe is ‘walked’ around the pockets / sulcus in all qualifying sextants, with the clinician recording the highest score in each. A light probing force of 20-25g should be used.

It is important to note that where a BPE score of 4 is recorded, all areas in the sextant should be examined, to ensure furcation involvements are not overlooked and to gain a better understanding of the patient’s periodontal health.5

The BSP’s guidance indicates that BPE codes should be scored as follows:5

0 – pockets <3.5mm, first black band completely visible, healthy periodontal tissues, no calculus/overhangs, no bleeding on probing.

1 – pockets <3.5mm, first black band completely visible, no calculus/overhangs, presence of bleeding on probing

2 – pockets <3.5mm, first black band completely visible, supra or subgingival calculus or plaque retention factor (overhang)

3 – probing depth 3.5mm to 5.5mm, first black band partially visible, indicating pocket of 4mm to 5mm

4 – probing depth >5.5mm, first black band entirely within the pocket, indicating pocket of 6mm or more

* – furcation involvement.

In terms of interpreting scores for practical purposes, BSP guidance further suggests:5

Code 0 – no need for periodontal treatment

Code 1 – provide oral hygiene instruction

Code 2 – provide oral hygiene instruction and remove plaque retentive factors, including both supra- and sub-gingival calculus

Code 3 – provide oral hygiene instruction, remove plaque retentive factors (including both supra- and sub-gingival calculus), and perform root surface debridement if appropriate

Code 4 – provide oral hygiene instruction and perform root surface debridement where required. In addition, assess the need for more involved treatment, for which a referral may be appropriate

* – Treat in line with BPE codes 1 to 4, as well as assessing the need to perform more complex dentistry, perhaps via a referral. (No treatment needed for code 0.)

Taking action at BPE 1

Tonetti and colleagues (2015) wrote that taking action upon the diagnosis of gingivitis is important because: ‘Gingivitis and periodontitis are inflammatory conditions caused by the formation and persistence of microbial biofilms on the hard, nonshedding surfaces of teeth. Gingivitis is the first manifestation of the inflammatory response to the biofilm. It is reversible (i.e. if the biofilm is disrupted gingivitis resolves), but if biofilms persist gingivitis becomes chronic. In some subjects, chronic gingivitis progresses to periodontitis.’8

They also wrote: ‘Periodontitis is characterised by non-reversible tissue destruction resulting in progressive loss of attachment eventually leading to tooth loss.’8

Therefore, if gingivitis is not resolved in a patient, it may develop into the irreversible, more destructive periodontitis: ‘Primary prevention of gingivitis aims to avoid the development of more severe and widespread forms of gingivitis that may ultimately convert to periodontitis.’8

The oral health gap

When a BPE of 1 is recorded and a diagnosis of gingivitis consequently made by the dentist: ‘Professional OHI [oral health instruction] should be provided to reduce plaque and gingivitis. Re-enforcement of OHI may provide additional benefits.’2

Tooth brushing is recommended to reduce plaque levels.2 Adding to this, the FDI’s 2018 ‘White Paper on Prevention and Management of Periodontal Diseases for Oral Health and General Health’ suggests: ‘The additional use of flosses and/or interdental brushes is essential for removal of interdental plaque. In addition, according to the Guidelines for Effective Prevention of Periodontal Diseases produced by the EFP (2015), some specific mouth rinses offer benefit in the management and prevention of gingivitis, as do certain chemical agents in dentifrices as an adjunct to mechanical plaque removal.9

Interdental cleaning, therefore, is another crucial aspect of a patient’s at-home regimen, as it is, ‘… essential in order to maintain interproximal gingival health…’.2

The use of a mouthwash as an adjunct may also help patients struggling to control plaque with mechanical methods alone. To this end, Chapple and colleagues (2015) wrote, ‘… where improvements in plaque control are required, adjunctive use of antiplaque chemical agents may be considered.’2

Evidence update

Indeed, an updated evidence base reaffirms the role of mouthwash in gum health.10

In 2019, Figuero and colleagues conducted a systematic review and meta-analysis exploring the adjunctive use of 11 different mouth rinse formulations.10

Their investigation established that adjunctive antiseptics in mouthwash provide statistically significant reductions in plaque compared to mechanical plaque control alone at six months.10

They also came to the conclusion that, ‘… despite the high variability in the number of studies comparing each active agent and the different risks of bias, CHX [chlorhexidine] and EOs [essential oils], in mouthrinses appeared to be the most effective active agents for plaque … control.’10

In addition, the Figuero and colleagues’ (2019) outcomes add to the pre-existing evidence base presented by Araujo and colleagues (2015), which was the first meta-analysis to demonstrate the clinically significant, site-specific benefit of adjunctive essential oil mouthwash in people within a 6-month period (that is, between dental visits).11

The analysis revealed that 36.9% of subjects using mechanical methods with essential oil-containing mouthwash experienced at least 50% plaque-free sites after 6 months, compared to just 5.5% of patients using mechanical methods alone.11

Mouthwashes available supporting gum health

Johnson & Johnson Ltd. have two products in its LISTERINE® range that help to support patients’ gum health – LISTERINE® Total Care and LISTERINE® Advanced Defence Gum Treatment.

It has been demonstrated that when used as an adjunct to mechanical cleaning, LISTERINE® Total Care, an essential oil mouthwash, manages plaque levels, to help prevent gingivitis.12

LISTERINE® Advanced Defence Gum Treatment is a twice-daily mouthwash clinically proven to treat gingivitis as an adjunct to mechanical cleaning.13

It is formulated with unique LAE (Ethyl Lauroyl Arginate) technology that forms a physical coating on the pellicle to prevent bacteria attaching, and so interrupts biofilm formation. When used after brushing, it helps to treat gingivitis as demonstrated by the reduction of bleeding by 50.9% (p<0.001) in just 4 weeks.13

With LISTERINE® Advanced Defence Gum Treatment clinically proven to interrupt the plaque colonisation process,13 this may offer a viable option in terms of supporting patients’ gum health.

References

1. Kinane DF, Attström R. Advances in the pathogenesis of periodontitis. Group B consensus report of the fifth European Workshop in Periodontology. J Clin Periodontol 2005; 32(Suppl. 6): 130-131

2. Chapple ILC et al. Primary prevention of periodontitis: managing gingivitis. J Clin Periodontol 2015; 42 (Suppl. 16): S71-S76

3. Chapple ILC et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. J Clin Periodontol. 2018; 45(Suppl 20): S68-S77

4. Proceedings of ground-breaking World Workshop on new classification are published.

https://www.efp.org/news-events/news/proceedings-of-ground-breaking-world-workshop-on-new-

classification-are-published-30194/. Accessed 19 October 2020

5. The Good Practitioner’s Guide to Periodontology. BSP 2016. https://www.bsperio.org.uk/assets/downloads/good_practitioners_guide_2016.pdf. Accessed 19 October 2020

6. https://www.bsperio.org.uk/assets/downloads/BSP_BPE_Guidelines_2019.pdf. Accessed 19 October 2020

7. Preshaw PM. Detection and diagnosis of periodontal conditions amenable to prevention. BMC Oral Health 2015; 15(Suppl 1): S5-S15

8. Tonetti et al. Principles in prevention of periodontal diseases. Consensus report of group 1 of the 11th European Workshop on Periodontology on effective prevention of periodontal and

peri-implant diseases. J Clin Periodontol 2015; 42 (Suppl. 16): S5-S11

9. White Paper on Prevention and Management of Periodontal Diseases for Oral Health and General Health. FDI World Dental Federation 2018

10. Figuero E et al. Efficacy of adjunctive therapies in patients with gingival inflammation. A

systematic review and meta-analysis. https://doi.org/10.1111/jcpe.13244; 23 December 2019

11. Araujo MWB et al. Meta-analysis of the effect of an essential oil–containing mouthrinse on gingivitis and plaque. JADA 2015; 146(8): 610-622

12. Boyle et al. Mouthwash use and the prevention of plaque, gingivitis and caries. Head & Neck Oral Diseases 2014; 20(1): 1-76

13. Gallob JT et al. A randomized trial of ethyl lauroyl arginate-containing mouthrinse in the control of gingivitis. J Clin Periodontol 2015; 42: 740-747

[J&J Reference]

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