Outstanding oral care should be accessible for all, prompting the demand for innovative oral hygiene products that meet every unique patient need. By doing so, good health across the rest of the body can be achieved. This is Curaprox’s mission: promoting overall health by improving oral health first.
Chlorhexidine is an antiseptic agent that reduces the number of bacteria in the oral cavity (when used in a mouthwash). Because of its effectiveness, chlorhexidine use is limited to the short-term; its bactericidal effect eliminates the good bacteria too. It’s therefore only suitable for the swift treatment of oral disease, as well as patients with no major health complications.[i] This leaves a gap in the mouthwash market.
Curaprox has risen to the challenge of making a powerful mouthwash that targets harmful bacteria without the need of chlorhexidine. Perio Plus Zero is a game-changing chlorhexidine-free alternative to its sister mouthwashes in the Curaprox range. The secret to its success? Quorum Quenching.
Ground-breaking science
Autoinducers are diffusible molecules that act as chemical signals and can modulate individual or group behaviours of bacteria. The regulation or disruption of this process, known as Quorum Quenching, inhibits bacterial communication and sits at the centre of Perio Plus Zero’s antibacterial approach.[ii]
Its formula uses a unique biohacking method that specifically targets the bacteria responsible for tooth decay: Streptococcus mutans. By interfering with the cellular communication of the bacteria, Perio Plus Zero prevents the formation of harmful colonies on the teeth and gingivae, reducing the risk of caries. The cutting-edge science of the mouthwash ensures that the good bacteria in the oral cavity – those that stop halitosis, help digestion and manage inflammation – are not eliminated, enhancing oral hygiene outcomes.[iii]
As Perio Plus Zero preserves and supports the oral microbiome without blasting away the good bacteria, it can be used flexibly and on a need basis to help manage common oral diseases for patients with compromised health conditions. This includes patients who:
- Are receiving treatment for cancer
- Are on end-of-life care
- Have autoimmune complications
- Cannot use Chlorhexidine
Whether paediatric or elderly, Perio Plus Zero gives vulnerable patients an oral hygiene alternative to chlorhexidine for a safer solution that doesn’t compromise on excellent outcomes, and doesn’t cause staining.
Recipe for success
The advanced science of Perio Plus Zero is grounded in a flavoursome taste. Among its active ingredients is Citroxâ, a natural extract derived from bitter oranges, and polylysine, which work together to reduce biofilm plaque build-up whilst ensuring a pleasant-tasting experience.
Other key ingredients include hyaluronic acid, a moisture binding substance that hydrates the soft tissues, and xylitol, an anti-caries agent that also stimulates saliva production. The addition of magnolol, found in the bark of the magnolia grandiflora tree, also has an antibacterial effect against Streptococcus mutans, as well as essential antioxidant properties to reduce inflammation.
Take on oral disease
Perio Plus Zero has a range of applications. It can tackle gingival problems, halitosis, xerostomia, and is ideal for those undertaking orthodontic treatment. For children, Curaprox recommends for those aged 6+, and once they can control their swallowing. Dental practitioners should determine which patients may benefit the most from Perio Plus Zero, including those who may refuse chlorhexidine because of its staining effect.[iv]
A short-term solution for many oral health complications, rinsing 10ml of Perio Plus Zero undiluted for 60 seconds twice a day improves oral hygiene standards. For patients with weakened immunity, the mouthwash allows them to reap the antibacterial rewards of chlorhexidine in a safer and more appropriate way, leaving no patient vulnerable to oral disease.
Look to the future with Curaprox
The product range from Curaprox is filled with the latest and greatest in oral hygiene solutions. Matching smooth Swiss aesthetics with reliable research and a strong understanding of patient needs and preferences, each Curaprox product levels-up the daily dental care routine. A healthy body starts with a healthy mouth – continue the journey with Perio Plus Zero and other products from Curaprox.
To arrange a Practice Educational Meeting with your Curaden Development Manager please email us on sales@curaden.co.uk
For more information, please visit www.curaprox.co.uk and www.curaden.co.uk
[i] NHS Choices (2024). About chlorhexidine – Brand names: Corsodyl, Covonia, Dermol, Germolene, Savlon. [online] NHS. Available at: https://www.nhs.uk/medicines/chlorhexidine/about-chlorhexidine/.
[ii] Sikdar, R. and Elias, M. (2020). Quorum quenching enzymes and their effects on virulence, biofilm, and microbiomes: a review of recent advances. Expert Review of Anti-infective Therapy, 18(12), pp.1221–1233. doi:https://doi.org/10.1080/14787210.2020.1794815.
[iii] www.colgate.com. (n.d.). Is There Good Bacteria In Your Mouth? | Colgate®. [online] Available at: https://www.colgate.com/en-us/oral-health/mouth-sores-and-infections/is-there-good-bacteria-in-your-mouth.
[iv] Nurdan Ozmeric, Ayaz Enver, Isler, S.C., Ceren Gökmenoğlu, Merve Topaloğlu, Hilal Selamet, Gökçen Altun and Selin Aykol Sayar (2025). Evaluating the effects of chlorhexidine and vitamin c mouthwash on oral health in non-surgical periodontal therapy: a randomized controlled clinical trial. Scientific Reports, [online] 15(1). doi:https://doi.org/10.1038/s41598-025-88100-6.
